Diabetes Res Clin Pract. 2004 Jul;65(1):7-11.
Aller R, de Luis DA, Izaola O, La Calle F, del Olmo L, Fernandez
L, Arranz T, Hernandez JM.
Institute of Endocrinology and Nutrition, Medicine School
and Hospital Rio Hortega, University of Valladolid, C/Los
Perales 16 (URB Las Acenas), Simancas, 47130 Valladolid, Spain.
The aim of our work was to carry out a randomized clinical
trial with two diets, one enriched in fiber (total fiber 30
g and soluble fiber 4 g) to investigate the effect on lipid
and glucose levels in healthy subjects.
RESEARCH DESIGN AND METHODS:
Fifty-three subjects were prospectively randomized to two
groups (see Table 1). Group I received a diet with 10.4 g
of fiber given as 1.97 g soluble fiber (pectins, gums and
mucilages) and 8.13 g of insoluble fiber (hemicelullose, cellulose
and lignins) and Group II received a diet with 30.5 g of fiber
of which 4.11 g were soluble fiber and 25.08 g insoluble fiber.
Prospective serial assessment of weight and nutritional intake
(3 days written food records) were made. These determinations
were performed at baseline and at 3 months. All enrolled subjects
underwent the following examinations; fasting blood samples
were drawn for measurement of total cholesterol, triglyceride
concentrations and other lipid fractions, low density lipoprotein
(LDL-cholesterol), high density lipoprotein (HDL-cholesterol),
glucose, and insulin. RESULTS: Total calorie and fat consumption
were lower than recommended in both groups (calories; group
I 1633+/-417 kcal per day versus group II 1707.5 +/- 579 kcal
per day:ns) and (fats; group I 73.4 +/- 22.7 g per day versus
group II [72.6 +/- 28 g per day:ns), without differences in
fatty acid intake profile. Total fiber intake did not reach
that recommended in both diets but it was higher in group
II ( 9.06 +/- 2.7 g per day versus 25.95 +/- 7.12 g per day:
P < 0.05). Soluble fiber intake did not reach that recommended
in both diets but it was higher in group II (1.7 +/- 0.58
g per day versus 3.5 +/- 0.96 g per day: P < 0.05). Body
weight did not change in both groups during treatment. During
treatment, in group II a significant change was detected from
baseline in LDL-cholesterol and fasting glucose levels. LDL-cholesterol
decreased by 12.8% (P < 0.05) and glucose decreased by
12.3% (P < 0.05). No statistical differences were detected
among triglycerides, HDL-cholesterol, and insulin levels.
Modest increases in soluble fiber intake in healthy subjects
improved LDL cholesterol and glucose levels.
Randomized Controlled Trial