Glucomannan prevents postprandial hypoglycaemia in patients with
previous gastric surgery.
Gut. 1988 Jul;29(7):930-4.
Hopman WP, Houben PG, Speth PA, Lamers CB.
Division of Gastroenterology, Radboud Hospital, University of Nijmegen,
Glucomannan (Propol), a potent gel forming dietary fibre, was added
to a carbohydrate rich breakfast in eight patients with previous gastric
surgery suffering from postprandial hypoglycaemia. Addition of only
2.6 g and 5.2 g glucomannan to the meal dose dependently improved reactive
hypoglycaemia from 2.3 (0.2) mmol/l to 3.3 (0.2) mmol/l (p less than
0.0005) after 2.6 g and 4.1 (0.2) mmol/l (p = 0.0005) after 5.2 g, and
decreased postprandial rise in plasma insulin (p less than 0.05). Expiratory
breath hydrogen excretion tended to decrease reflecting improvement
of carbohydrate metabolism. Addition of glucomannan to an intraduodenal
sucrose solution significantly raised plasma glucose nadirs, indicating
glucomannan to be effective during the intestinal phase. It is concluded
that small amounts of glucomannan may be beneficial to patients with
reactive postprandial hypoglycaemia, without the disadvantage of unpalatability
and carbohydrate malabsorption.