The use of highly purified glucomannan-based fibers in childhood obesity
Pediatr Med Chir. 1992 Mar-Apr;14(2):195-8. [Article in Italian]
Livieri C, Novazi F, Lorini R.
Clinica Pediatrica, Universita di Pavia, Italia.
To evaluate the effectiveness of highly purified glucomannan in childhood
obesity a study has been carried out in 23 obese children (12 boys and
11 girls, aged 5.2-15.8 years), with excess weight of 51 +/- 16%, treated
with 2-3 caps twice a day of glucomannan fibres (DICOMAN 5:2-3 gr/die),
and in 30 obese children (aged 5-18 years) with excess weight of 51
+/- 10%, studied as controls. After a three-days food recall, a balanced
diet with adequate caloric intake was provided to all obese children.
In all patients before and 2-4 months after the auxological data (weight,
height, weight excess) and laboratory data (serum levels of cholesterol,
HDL, triglycerides, glucose, fructosamine, glycosylated hemoglobin,
RBC, WBC, hemoglobin, iron, calcium, Cu and Zn) have been determined.
Excess weight and triglycerides levels were significantly decreased
in treated obese patients than in obese controls 4 months after the
beginning of the study. A decrease of cholesterol levels was also observed
in treated obese patients, but not in controls, whereas serum iron,
calcium, copper and zinc persisted unchanged. No important side-effects
were observed in treated patients. On the basis of our results highly
purified glucomannan fibres may be employed with effectiveness in obese
and dyslipidemic children together with diet.
Randomized Controlled Trial