Effect of dietary fiber, glucomannan, on absorption of sulfonylurea
Horm Metab Res. 1983 Jan;15(1):1-3.
Shima K, Tanaka A, Ikegami H, Tabata M, Sawazaki N, Kumahara Y.
In order to clarify whether a dietary fiber has any effect upon the
intestinal absorption of sulfonylurea, changes in plasma concentration
of glibenclamide were determined during a six-hour period in nine healthy
volunteers who took 2.5 mg of glibenclamide together with a breakfast
and 3.9 g of glucomannan in a form of konjac powder and were compared
with those of the control experiment in which the same amount of the
hypoglycemic agent was given without the dietary fiber. In the control,
mean plasma glibenclamide level increased rapidly, reaching a peak at
60 min and decreased gradually thereafter, whereas an increase in plasma
glibenclamide level was blunted in the test experiment, thus plasma
concentration of glibenclamide being lower at 30, 60, 90 and 150 min
compared with the corresponding value of the control (31.7 +/- 24.5
ng/ml vs 76.4 +/- 25.0 ng/ml at 30 min; 51.3 +/- 35.5 ng/ml vs 120.9
+/- 56.0 ng/ml at 60 min; 60.0 +/- 38.8 ng/ml vs 117.4 +/- 53.1 ng/ml
at 90 min; 54.0 +/- 31.5 ng/ml vs 100.7 +/- 46.5 ng/ml at 150 min).
Mean plasma glucose concentration was significantly lower at 30 min
in the test experiment than in the control despite the lower level of
plasma glibenclamide in the former. The results suggest that glucomannan
may influence the intestinal absorption of glibenclamide. A dietary
fiber must be prescribed in due consideration of these facts.