Chronic use of glucomannan in the dietary treatment of severe obesity
Minerva Med. 1992 Mar;83(3):135-9. [Article in Italian]
Vita PM, Restelli A, Caspani P, Klinger R.
Centro per la Farmacoterapia delle Malattie Nutrizionali, Universita
degli Studi di Milano.
Two groups of 25 severely obese patients underwent 3 months of hypocaloric
diet therapy either alone or associated with a glucomannan-based fibrous
diet supplement (approx. 4 g/die in 3 doses). The comparative analysis
of the results obtained in both groups showed that the diet + glucomannan
group had a more significant weight loss in relation to the fatty mass
alone, an overall improvement in lipid status and carbohydrate tolerance,
and a greater adherence to the diet in the absence of any relevant side
effects. Due to the marked ability to satiate patients and the positive
metabolic effects, glucomannan diet supplements have been found to be
particularly efficacious and well tolerated even in the long-term treatment
of severe obesity.
Randomized Controlled Trial