Effect of short-term ingestion of konjac glucomannan on serum cholesterol
in healthy men.
Am J Clin Nutr. 1995 Mar;61(3):585-9.
Arvill A, Bodin L.
Department of Clinical Physiology and Occupational Medicine, Orebro
Medical Centre Hospital, Sweden.
The effects of the soluble fiber konjac glucomannan (GM) on serum cholesterol
concentrations were investigated in 63 healthy men in a double-blind
crossover, placebo-controlled study. After a 2-wk baseline period, the
subjects were given 3.9 g GM or placebo daily for 4 wk. After a washout
period of 2 wk, crossover took place, followed by another 4 wk of treatment.
The subjects were encouraged not to change their ordinary diets or general
lifestyle during the investigation. GM fibers reduced total cholesterol
(TC) concentrations by 10% (P < 0.0001), low-density-lipoprotein
cholesterol (LDL-C) concentrations by 7.2% (P < 0.007), triglycerides
by 23% (P < 0.03), and systolic blood pressure by 2.5% (P < 0.02).
High-density-lipoprotein cholesterol (HDL-C) and the ratio of LDL-C
to HDL-C did not change significantly. No change in diastolic blood
pressure or body weight was observed. No adverse effects were observed.
The results of this study show that GM is an effective cholesterol-lowering
Randomized Controlled Trial