| Am J Clin Nutr 1995 Mar;61(3):585-9
Effect of short-term ingestion
of konjac glucomannan on serum cholesterol in healthy men.
Arvill A, Bodin L.
Department of Clinical Physiology and Occupational Medicine,
Orebro Medical Centre Hospital, Sweden.
The effects of the soluble fiber konjac glucomannan (GM) on
serum cholesterol concentrations were investigated in 63 healthy
men in a double-blind crossover, placebo-controlled study. After
a 2-wk baseline period, the subjects were given 3.9 g GM or
placebo daily for 4 wk. After a washout period of 2 wk, crossover
took place, followed by another 4 wk of treatment. The subjects
were encouraged not to change their ordinary diets or general
lifestyle during the investigation. GM fibers reduced total
cholesterol (TC) concentrations by 10% (P < 0.0001), low-density-lipoprotein
cholesterol (LDL-C) concentrations by 7.2% (P < 0.007), triglycerides
by 23% (P < 0.03), and systolic blood pressure by 2.5% (P
< 0.02). High-density-lipoprotein cholesterol (HDL-C) and
the ratio of LDL-C to HDL-C did not change significantly. No
change in diastolic blood pressure or body weight was observed.
No adverse effects were observed. The results of this study
show that GM is an effective cholesterol-lowering dietary adjunct.
- Clinical Trial
- Randomized Controlled Trial