| G E N 1995 Jan-Mar;49(1):7-14
Use of glucomannan dietary
fiber in changes in intestinal habit
[Article in Spanish]
Marsicano LJ, Berrizbeitia ML, Mondelo A.
Hospital Vargas de Caracas, Servicio de Gastroenterologia.
It has been proven that fiber is effective in the treatment
of multiple nosological entities, specially of the colonic pathology.
In the present study, two dose of Glucomannan (3 gr/day and
4 gr/day) were evaluated within the modification of the intestinal
habit and stool characteristics. 60 patients were included in
a random, parallel, double blind, cross over trial study versus
placebo. The modification of the intestinal habit was evaluated
through variations of daily and weekly evacuations, appraising
the stool's consistency and size, satiety after meals tiresomeness
between meals, constipation, diarrhea and flatulence. An increase
in the number of daily and weekly evacuations during the Glucomannan
vs placebo treatment was appreciated and, between the two dose
of Glucomannan, a difference was observed as to the large the
dose, the large the number of daily and weekly evacuations.
Evacuations during the phase of Glucomannan 3 gr/day increased
0.5 times per day, 3 more per week above baseline values. On
the 4 gr/day treatment of Glucomannan evacuations increased
0.9 times per day, 6 more per week above baseline values. Patient
during the placebo period presented no statistically significant
different. No difference was appreciated as to post-meal satiety,
nor tiresomeness between meals, possibly due to treatment periods
being 5 weeks long. No larger number of cases with diarrhea
or flatulence were appreciated with the use of Glucomannan.
Glucomannan proved to be superior to placebo, and the 3 gr/day
and 4 gr/day doses turned out to beneficial in the improvement
of the assessed parameters--better results were obtained using
4 gr/day of Glucomannan than 3 gr/day.
- Clinical Trial
- Randomized Controlled Trial