| Pediatr Med Chir 1992 Mar-Apr;14(2):195-8
The use of highly purified
glucomannan-based fibers in childhood obesity
[Article in Italian]
Livieri C, Novazi F, Lorini R.
Clinica Pediatrica, Universita di Pavia, Italia.
To evaluate the effectiveness of highly purified glucomannan
in childhood obesity a study has been carried out in 23 obese
children (12 boys and 11 girls, aged 5.2-15.8 years), with excess
weight of 51 +/- 16%, treated with 2-3 caps twice a day of glucomannan
fibres (DICOMAN 5:2-3 gr/die), and in 30 obese children (aged
5-18 years) with excess weight of 51 +/- 10%, studied as controls.
After a three-days food recall, a balanced diet with adequate
caloric intake was provided to all obese children. In all patients
before and 2-4 months after the auxological data (weight, height,
weight excess) and laboratory data (serum levels of cholesterol,
HDL, triglycerides, glucose, fructosamine, glycosylated hemoglobin,
RBC, WBC, hemoglobin, iron, calcium, Cu and Zn) have been determined.
Excess weight and triglycerides levels were significantly decreased
in treated obese patients than in obese controls 4 months after
the beginning of the study. A decrease of cholesterol levels
was also observed in treated obese patients, but not in controls,
whereas serum iron, calcium, copper and zinc persisted unchanged.
No important side-effects were observed in treated patients.
On the basis of our results highly purified glucomannan fibres
may be employed with effectiveness in obese and dyslipidemic
children together with diet.
- Clinical Trial
- Randomized Controlled Trial