| Ital J Gastroenterol 1991 Sep-Oct;23(7):421-5
Action of glucomannans
on complaints in patients affected with chronic constipation:
a multicentric clinical evaluation.
Passaretti S, Franzoni M, Comin U, Donzelli R, Rocca F, Colombo
E, Ferrara A, Dinelli M, Prada A, Curzio M, et al.
Istituto di Medicina Interna, Universita di Milano, Italy.
Chronic constipation is a very frequent disease in western countries
but fibres can often solve the problem. In the present study,
authors tested the efficacy and the acceptability of glucomannans,
hydrophylic carbohydrates with a high degree of viscosity, in
93 patients affected with chronic constipation. The multicentric,
open and non-controlled study was divided into an initial phase
(treatment with 1g of glucomannans t.i.d. for 1 month) and a
maintenance phase (1g b.i.d. for one month). We evaluated both
objective parameters (number of days per week with bowel movements
and number of enemas) and abdominal symptoms. After one month
all assessed parameters showed a statistically significant improvement
lasting through the second month. Glucomannans were well accepted
and devoid of relevant side-effects. In conclusion, considering
their efficacy and tolerability, they can be proposed as an
ideal therapeutic tool in the management of chronic constipation