| Diabetes Res Clin Pract 1991 Sep;13(3):147-52
Effects of long-term high-fiber
diet on macrovascular changes and lipid and glucose levels in
STZ-induced diabetic SD rats.
Yoshida M, Sawa J, Hozumi T, Mimoto H, Ishida Y, Kazumi T,
Doi K, Baba S.
Hyogo Medical Center for Adults, Japan.
The effects of long-term high-fiber diet on lipid and glucose
levels and the histological changes in the coronary arteries
and thoracic aorta in STZ-induced diabetic SD rats were investigated.
During the first 4 weeks of the study period, all diabetic rats
were given regular chow plus water after which, all were grouped
according to the following diet regimen: group II, no added
cholesterol and glucomannan; group III, no added cholesterol
but with glucomannan supplement, group IV, with added
cholesterol but no glucomannan supplement; and group
V, with both cholesterol and glucomannan supplements.
15% weight of glucomannan and 1.5% weight of cholesterol in
regular rat chow were used as supplements when indicated. Non-diabetic
rats which received only regular chow served as the control
group (group I). In the 18th week all rats were sacrificed and
weight gain, glucose, total cholesterol, HDL-cholesterol, triglyceride
and lipid peroxidase concentrations were determined. Selected
portions of the heart and thoracic aorta were histologically
examined. Weight gain was higher in rats supplemented with glucomannan
than in those without glucomannan supplements, but the difference
is not significant. A lowering tendency in glucose levels was
likewise observed. Furthermore, total cholesterol and HDL-cholesterol
levels were lower and higher, respectively in diabetic rats
receiving glucomannan. Although the triglyceride levels were
similar in all rats, lipid peroxidase levels were significantly
lower in rats with high-fiber diet.